L-Asparaginase is an enzyme-based chemotherapy medicine used mainly in blood cancers.
It works by depleting the amino acid asparagine from the bloodstream. Leukemic cells (especially in ALL) cannot synthesize asparagine on their own, so depletion leads to inhibition of protein synthesis and cell death.
It is administered by intravenous (IV) or intramuscular (IM) injection under strict medical supervision.

L-Asparaginase Injection 10,000 IU is used for:

• Acute Lymphoblastic Leukemia (ALL)

  • In children and adults

• Lymphoblastic lymphoma

• As part of combination chemotherapy regimens

Common Side Effects

• Nausea and vomiting

• Loss of appetite

• Fatigue

• Fever

• Injection-site pain (IM route)

Serious Side Effects

• Hypersensitivity reactions / Anaphylaxis

  • Rash, itching, breathlessness, shock

• Pancreatitis (severe abdominal pain)

• Liver toxicity

  • Elevated liver enzymes, jaundice

• Coagulation abnormalities

  • Bleeding or thrombosis

• Hyperglycemia

• Hypoalbuminemia

• CNS effects (confusion, drowsiness – rare)

Dosage is protocol-based and determined by an oncologist.

Typical Dosage (General Reference)

• Children & Adults:

  • 5,000–10,000 IU/m² per dose

  • Given IM or IV

  • Frequency, Every other day or 2–3 times per week (as per chemotherapy protocol)